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Special Spotlight On Diabetes Insulins: Jardiance (empagliflozin)

Medically reviewed by Catherine C. Peng, PharmD, BCPS on Four/17/19. Written by Lindsay Slowiczek, PharmD.

Republished with permission from Healthline.

In a particular partnership, dLife is proud to deliver our readers an informative new collection on the varied varieties of insulin available on the market, courtesy of Healthline’s Medical Community.

We hope you find this collection useful. Healthline has made each effort to make certain that each one info is factually right, complete, and up-to-date.

Nevertheless, this article shouldn’t be used as an alternative to the information and experience of a licensed healthcare skilled.

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Contents

What’s Jardiance?

Jardiance is a brand-name prescription medicine that’s prescribed for individuals with Sort 2 diabetes. It’s used to:

  • improve blood sugar ranges, together with improved weight loss plan and exercise
  • scale back the danger of cardiovascular demise in individuals with heart disease in addition to sort 2 diabetes
  • Jardiance incorporates the drug empagliflozin. It belongs to a category of medicine referred to as sodium-glucose co-transporter 2 (SGLT2) inhibitors. Jardiance comes as a pill that’s taken by mouth once day by day.

Effectiveness

In medical research, Jardiance improved blood sugar levels in adults with diabetes. After 24 weeks of remedy, individuals taking Jardiance had the following results:

  • Hemoglobin A1c (HbA1c) ranges have been lowered by zero.7 % to zero.eight %.
  • Fasting blood sugar levels have been lowered by 19 mg/dL to 25 mg/dL.
  • Body weight was lowered by 2.8 % to three.2 % from their starting weight.
  • Jardiance can also be effective when taken in combination with different diabetes drugs. It can be taken with medicine reminiscent of metformin, insulin, pioglitazone, and glipizide.

In a three-year medical research, Jardiance helped scale back the danger of cardiovascular demise by 38 % in individuals with each Sort 2 diabetes and coronary heart disease. In this research, individuals took Jardiance in combination with other remedy for diabetes and heart disease.

Jardiance generic

Jardiance is on the market solely as a brand-name treatment. It’s not presently out there in generic type.

Jardiance incorporates the drug empagliflozin.

Jardiance uncomfortable side effects

Jardiance may cause delicate or critical unwanted effects. The following record accommodates a few of the key unwanted side effects which will occur while taking Jardiance. This listing does not embrace all attainable unwanted effects.

For more info on the attainable unwanted effects of Jardiance, or recommendations on the right way to cope with a troubling aspect impact, speak together with your doctor or pharmacist.

More widespread uncomfortable side effects

The extra widespread unwanted effects of Jardiance can embrace:

  • urinary tract infections, with signs resembling burning while urinating, urinating more typically, and cloudy urine
  • vaginal yeast infections, with signs corresponding to itching, soreness, and ache whereas urinating
  • When you’ve got signs of these infections, call your doctor. You could need remedy with over-the-counter or prescription drugs.

Critical unwanted side effects

Critical unwanted side effects from Jardiance aren’t widespread, however they will occur. Call your physician instantly when you’ve got critical uncomfortable side effects. Call 911 in case your symptoms feel life-threatening or in the event you assume you’re having a medical emergency.

Critical uncomfortable side effects and their symptoms can embrace the next:

  • Hypotension (low blood strain). Signs can embrace: lightheadedness, feeling dizzy or falling when standing up
  • clammy skin
  • lack of consciousness
  • melancholy
  • Kidney injury. Symptoms can embrace: decreased urination
  • swelling in legs and ankles
  • confusion
  • fatigue
  • Elevated low-density lipoprotein (LDL) levels of cholesterol
  • Different critical uncomfortable side effects, defined in more element under in “Side effect details,” embrace:
  • Ketoacidosis (buildup of ketones within the physique, inflicting your blood to be too acidic)
  • Critical urinary tract infections (including urosepsis and pyelonephritis)
  • Fournier’s gangrene (severe an infection close to the genitals)
  • Genital yeast infections (in men and women)
  • Critical allergic reactions
  • Aspect effect particulars
  • Chances are you’ll marvel how typically certain negative effects happen with this drug, or whether sure unwanted effects pertaining to it.

Here’s some detail on a few of the unwanted effects this drug might or might not trigger:

Allergic response

As with most medicine, some individuals can have an allergic reaction after taking Jardiance. Symptoms of a light allergic reaction can embrace:

  • pores and skin rash
  • itchiness
  • flushing (warmth and redness in your skin)

A more severe allergic response is uncommon however potential. Signs of a severe allergic response can embrace:

  • angioedema (swelling underneath your skin, sometimes in your eyelids, lips, arms, or ft)
  • swelling of your tongue, mouth, or throat
  • hassle respiration
  • Call your doctor immediately when you have a extreme allergic reaction to Jardiance. Call 911 in case your signs really feel life-threatening or in case you assume you’re having a medical emergency.

Gangrene

Gangrene is a kind of an infection that causes tissue within the body to die. Gangrene did not happen in individuals taking Jardiance during medical studies. Nevertheless, it has been reported after medical trials ended. Gangrene has occurred in individuals taking Jardiance or other drugs in the same drug class.

A kind of gangrene referred to as Fournier’s gangrene has been reported in individuals taking Jardiance. Fournier’s gangrene is rare however very critical. It causes tissue within the genital space to turn into infected and die.

Symptoms of Fournier’s gangrene embrace:

  • ache, redness, or swelling near the genitals or rectum
  • fever or chills
  • an general feeling of discomfort
  • In the event you experience these symptoms, call your doctor immediately. One of these gangrene requires speedy medical care. Remedy can embrace treatment or hospitalization. It could possibly even involve surgical procedures, including genital amputation.

Urinary tract infection

Urinary tract an infection (UTI) was probably the most widespread uncomfortable side effects seen during medical studies of Jardiance. This affected both women and men but was more widespread in ladies than men. Urinary tract infections occurred in 17.0 % to 18.Four % of girls. They solely occurred in three.6 % to Four.1 % of males.

Signs of a UTI can embrace:

  • frequent urination
  • burning sensation when urinating
  • urine with a robust odor
  • darkish or cloudy urine
  • pelvic pain in ladies
  • rectal or pelvic ache in males
  • ache in the sides of your again
  • fever or chills
  • nausea
  • vomiting
  • fatigue (low power)
  • If left untreated, UTIs can turn into critical. They could cause a kidney infection. Name your doctor when you’ve got any UTI symptoms. A UTI is often handled with antibiotics.

Genital yeast infections

Genital yeast infections have been a very common aspect impact during Jardiance medical research. They have been more widespread in ladies than in men. Yeast infections have been reported in 5.Four % to 6.Four % of girls. Of males, 1.6 % to 3.1 % had yeast infections.

Signs of yeast infections that occur in the genital space can embrace:

  • redness
  • itchiness
  • rash
  • pain or soreness
  • swelling
  • thick white discharge
  • Name your doctor if in case you have symptoms of a yeast infection. Yeast infections can develop into critical. In rare instances, without remedy, they will lead to Fournier’s gangrene (see “Gangrene” above). Your physician will advocate over-the-counter or prescribed drugs to deal with genital yeast infections.

Ketoacidosis

During medical research, individuals taking Jardiance didn’t have an elevated danger of ketoacidosis. Nevertheless, since medical studies ended, ketoacidosis has been reported in some individuals taking Jardiance. It’s not recognized how many people expertise ketoacidosis while taking Jardiance.

Individuals with ketoacidosis have abnormally excessive quantities of ketones (a kind of protein) in their body. Your physique usually makes ketones after breaking down fat out of your food regimen. Jardiance causes your physique to make extra ketones. A buildup of ketones in the physique may cause the blood to be too acidic.

Symptoms of ketoacidosis can embrace:

  • excessive blood sugar ranges
  • high ketone ranges within the urine
  • extreme thirst
  • frequent urination
  • nausea
  • stomach (belly) pain
  • vomiting
  • fruity-smelling breath
  • speedy respiration
  • coma
  • Ketoacidosis might be life-threatening and requires fast medical remedy.

Joint ache

In medical studies, round 2.4 % of people who took Jardiance had joint ache. Nevertheless, 2.2 % of people who took the placebo (a capsule that doesn’t include any lively drug) additionally reported joint ache. Because each the people who took the drug and people who didn’t take it had comparable results, it’s not clear if the joint pain was associated to Jardiance.

If in case you have joint pain while taking Jardiance, speak together with your physician about methods to scale back it.

Pancreatitis

A evaluation Trusted Source of 15 medical studies seemed at the danger of getting pancreatitis (inflammation of the pancreas) whereas taking Jardiance. The outcomes showed that folks taking Jardiance have lower than a zero.1 % danger of pancreatitis.

If in case you have had pancreatitis up to now, chances are you’ll be at larger danger of having this situation whereas taking Jardiance. Speak together with your doctor about your danger of creating pancreatitis whereas taking Jardiance.

Rash

Skin rashes may be a aspect impact of Jardiance. In medical research, rash sometimes occurred as a symptom of yeast infections, which frequently cause purple, irritated skin. Yeast infections have been a standard aspect effect in these medical studies (see “Genital yeast infections” above).

Because the medical trials passed off, pores and skin rash and itchiness have been in reported in individuals utilizing Jardiance. Nevertheless, it’s not recognized how widespread this aspect effect may be.

Stomach pain

Ache within the abdomen (stomach) was not a aspect impact reported in medical research of Jardiance. Nevertheless, stomach ache might be a symptom of other uncomfortable side effects of Jardiance. As an example, lower stomach ache and pelvic pain may be brought on by urinary tract infections. Ketoacidosis also can cause stomach pain.

If in case you have pain in your stomach whereas taking Jardiance, speak together with your physician about attainable causes and ways to deal with it.

Hair loss (not a aspect effect)

Hair loss was not reported throughout medical research of Jardiance. In case you are involved about hair loss, speak together with your physician about attainable causes and cures.

Heart failure (not a aspect effect)

Jardiance just isn’t recognized to trigger heart failure. In reality, Jardiance and others in the identical drug class are thought to protect the guts and blood vessels.

These medicine work by decreasing the body’s blood strain. This decreases how arduous the guts has to work. The medicine also scale back blood strain in the kidneys, which may improve the best way the guts works.

One research looked at more than 7,000 individuals with diabetes who took Jardiance. On this research, Jardiance decreased the danger of cardiovascular dying and lowered the danger of being hospitalized for heart failure. This profit was seen in individuals with and with no history of heart failure.

Constipation (not a aspect impact)

Constipation was not reported during medical research of Jardiance. Nevertheless, Jardiance might trigger dehydration in some individuals. Dehydration (low bodily fluids) can typically result in constipation.

Constipation can also be widespread in individuals with diabetes. Diabetes may cause nerve injury within the bowels. These nerves are chargeable for helping keep regular bowel actions.

In case you are involved about constipation, speak together with your doctor about ways to maintain your system regular.

Fatigue (not a aspect impact)

Fatigue (low power ranges) was not a aspect impact brought on by Jardiance in medical research. Nevertheless, it can be a symptom of unwanted effects of Jardiance, comparable to urinary tract infections. Additionally, many individuals with diabetes have fatigue.

In the event you feel abnormally tired or are bothered by fatigue, speak together with your doctor about attainable causes. Your doctor can advocate methods to help improve your power ranges.

Again pain (not a aspect effect)

Back pain was not reported as a aspect impact of Jardiance in medical research. Nevertheless, back pain could also be a symptom of different unwanted side effects brought on by Jardiance.

One example of that is urinary tract infections (see “Urinary tract infection” above).These infections may cause pain in your back. The ache sometimes occurs on the edges of the center of your again, where your kidneys are situated.

In case you are having again pain, speak together with your physician. They will determine whether the back ache is brought on by a UTI or another situation.

Diarrhea (not a aspect effect)

Diarrhea was not a aspect effect reported in medical studies of Jardiance. Nevertheless, diarrhea may be brought on by diabetes itself. Diarrhea may also be a aspect effect of other diabetes drugs, akin to metformin.

If in case you have diarrhea whereas taking Jardiance, speak to your physician about ways to manage this aspect effect.

Jardiance and metformin

Jardiance may be utilized in mixture with metformin to help lower blood sugar ranges. Metformin is one other drug used to deal with Sort 2 diabetes. Several medical research have proven that Jardiance and metformin are effective in treating diabetes when used together.

Metformin is a prescription medicine that comes as a pill and a solution. Both the tablet and answer are taken by mouth.

Metformin is accessible as a generic drug and a number of other brand-name medicine. These brand-name medicine embrace:

  • Glucophage
  • Glucophage XR
  • Fortamet
  • Glumetza
  • Riomet

If your physician want to treat you with both empagliflozin (the lively ingredient in Jardiance) and metformin, they could prescribe Synjardy. Synjardy is a single pill that accommodates a mixture of those two medicine. Synjardy comes as an immediate-release pill and an extended-release pill (Synjardy XR).

Jardiance use with other medicine

Jardiance can be utilized alone or in combination with different diabetes drugs to treat sort 2 diabetes. If one drug does not lower your blood sugar ranges sufficient, your physician might prescribe a number of medicine to be taken collectively.

Examples of diabetes drugs that can be taken with Jardiance embrace:

  • metformin (Glucophage, Glumetza, Fortamet, Riomet)
  • glimepiride (Amaryl)
  • glipizide (Glucotrol)
  • glyburide (Diabeta, Glynase)
  • pioglitazone (Actos)
  • dulaglutide (Trulicity)
  • exenatide (Byetta, Bydureon)
  • liraglutide (Victoza)
  • lixisenatide (Adlyxin)
  • semaglutide (Ozempic)
  • alogliptin (Nesina)
  • saxagliptin (Onglyza)
  • sitagliptin (Januvia)
  • insulin, comparable to insulin glargine (Lantus, Basaglar, Toujeo)

Jardiance interactions

Jardiance can work together with a number of other drugs. It will probably also interact with certain supplements as well as sure foods.

Totally different interactions may cause totally different results. As an example, some interactions can intrude with how nicely a drug works. Different interactions may cause increased unwanted effects.

Jardiance and different drugs

Under is an inventory of medicines that can interact with Jardiance. This record does not include all medicine which will interact with Jardiance.

Before taking Jardiance, make sure you tell your physician and pharmacist about all prescription, over-the-counter, and other medicine you’re taking. Additionally tell them about any vitamins, herbs, and dietary supplements you employ. Sharing this info might help you keep away from potential interactions.

If in case you have questions about drug interactions which will have an effect on you, ask your physician or pharmacist.

Jardiance and insulin and different diabetes medicine
Diabetes medicine are sometimes taken collectively to decrease blood sugar ranges. Nevertheless, taking Jardiance with sure diabetes medicine can improve your danger for hypoglycemia (low blood sugar). These medicine embrace insulin and other drugs that improve insulin ranges in the body.

Examples of insulin drugs embrace:

  • insulin aspart (Novolog)
  • insulin lispro (Humalog)
  • insulin glulisine (Apidra)
  • common insulin (Humulin R, Novolin R)
  • insulin NPH (Humulin N, Novolin N)
  • insulin glargine (Lantus, Basaglar, Toujeo)
  • insulin detemir (Levemir)
  • insulin degludec (Tresiba)
  • premixed insulins (Humalog 50/50, Novolin 70/30)

Examples of different diabetes medicine that can improve your danger of hypoglycemia if taken with Jardiance embrace:

  • nateglinide (Starlix)
  • tolbutamide
  • glyburide (Diabeta, Glynase)
  • glipizide (Glucotrol)
  • glimepiride (Amaryl)

Speak to your doctor concerning the danger of hypoglycemia with every diabetes treatment you’re taking. Additionally, speak about how the danger is increased for those who take a mixture of diabetes medicine. Your doctor might regulate the dosage of Jardiance or your other diabetes drugs to scale back the danger of hypoglycemia.

Jardiance and certain blood strain medicine

Taking Jardiance with certain blood strain drugs, resembling diuretics (water drugs), can improve the danger of low blood strain. It’s because diuretic medicine and Jardiance each improve urination. Urination moves fluid out of the physique. This could result in dehydration (low bodily fluids) and low blood strain.

Examples of diuretics embrace:

  • hydrochlorothiazide (Microzide)
  • chlorthalidone
  • furosemide (Lasix)
  • torsemide (Demadex)
  • spironolactone (Aldactone, Carospir)
  • triamterene (Dyrenium)

Many blood strain drugs are created from a mixture of medicine. Typically one of the medicine in the mixture is a diuretic. Be sure you tell your physician about all blood strain medicine you’re taking to avoid a possible interaction.

Jardiance and caffeine

Jardiance and caffeine can both cause elevated urination. One small research found that this improve in urine output brought on by Jardiance might help the drug lower blood sugar.

Nevertheless, increased urination may also trigger dehydration (low bodily fluids) and low blood strain. That is more more likely to happen should you eat an excessive amount of caffeine. If caffeine is part of your food regimen, speak together with your physician about how much caffeine is protected for you.

Jardiance and alcohol

There isn’t any direct interaction between Jardiance and alcohol. Nevertheless, consuming an excessive amount of alcohol while taking Jardiance can worsen sure results of Jardiance.

For example, both Jardiance and alcohol can improve urination. Taking Jardiance and alcohol collectively can improve the danger of dehydration (low bodily fluids) and low blood strain.

Additionally, consuming an excessive amount of alcohol whereas taking Jardiance (or comparable drugs) might improve the danger of ketoacidosis. With this situation, giant quantities of ketones (a kind of protein) construct up in your blood.

Your physique normally makes ketones after breaking down fat out of your food regimen. Consuming alcohol may cause your body to make extra ketones than regular. Jardiance additionally makes your body produce ketones. A buildup of ketones in the body may cause the blood to be too acidic.

Ketoacidosis requires instant medical remedy because it may be life-threatening.

In response to the American School of Endocrinology, individuals taking Jardiance or other medicine from the identical class (SGLT2 inhibitors) ought to avoid extreme alcohol consumption. This helps to scale back the danger of ketoacidosis.

Jardiance dosage

The Jardiance dosage your physician prescribes will rely upon how properly your physique responds to the treatment.

Sometimes, your doctor will start you on a low dosage and regulate it over time to succeed in the dosage that’s best for you. They’ll finally prescribe the smallest dosage that gives the desired effect.

The next info describes dosages which are generally used or advisable. Nevertheless, be sure you take the dosage your doctor prescribes for you. Your physician will decide the perfect dosage to fit your wants.

Drug varieties and strengths

Jardiance comes as a tablet that’s taken by mouth. It’s obtainable in two strengths: 10 mg and 25 mg.

Dosage for adults with Sort 2 diabetes

The beginning dosage of Jardiance is 10 mg as soon as every day. It must be taken in the morning with or with out food.

If Jardiance is working nicely for you, your physician might improve your dosage. The utmost dosage of Jardiance is 25 mg per day.

What if I miss a dose?

In the event you miss a dose of Jardiance, take it as soon as you keep in mind. If it’s virtually time on your next dose, just take that one dose.

Don’t take two doses on the similar time. This may increasingly lead to increased uncomfortable side effects.

Will I want to use this drug long run?

It depends. Should you and your doctor determine that Jardiance is effective and protected for you, you might have to take it long term to help handle diabetes.

Jardiance makes use of

The Meals and Drug Administration (FDA) approves prescribed drugs akin to Jardiance to deal with sure circumstances. Jardiance may additionally be used off-label for other circumstances. Off-label use is when a drug that’s authorised to deal with one situation is used to deal with a unique situation.

Jardiance for diabetes

Jardiance is FDA-approved to decrease blood sugar ranges in adults with Sort 2 diabetes. It’s permitted to be used in combination with food regimen and train.

Jardiance for decreasing the danger of cardiovascular demise

Jardiance is FDA-approved to decrease the danger of demise brought on by heart disease in adults with each Sort 2 diabetes and heart disease.

Jardiance for weight loss

Jardiance isn’t accredited for weight reduction, however weight reduction is a potential aspect impact of the medicine.

In a medical research, individuals who took Jardiance alone or with other diabetes medicine misplaced between 1.eight % and three.2 % of their body weight. This weight loss was seen over 24 weeks of remedy.

In one other medical research, individuals who took Jardiance with metformin misplaced a mean of three.9 % of their body weight. This research lasted 52 weeks.

It’s thought that Jardiance causes weight reduction by helping the physique lose sugar. Jardiance prevents the kidneys from absorbing blood sugar (glucose) back into the body. The sugar, and its energy, then depart the body within the urine. Consequently, the physique has fewer calories to process, which can result in weight loss.

Word: Jardiance isn’t FDA-approved as a medicine for weight loss. It ought to only be used in accordance with your doctor’s prescription. You shouldn’t take Jardiance for weight reduction or some other function without your doctor’s suggestion.

Options to Jardiance

Different medicine can be found that can deal with your situation. Some could also be better fitted to you than others. When you’re considering discovering an alternative choice to Jardiance, speak to your physician to study more about different drugs which will work properly for you.

Options for Sort 2 diabetes

Under are examples of other medicine which might be used to treat Sort 2 diabetes. Some of these drugs are in the identical drug class as Jardiance, and some are in a unique drug class. These totally different drug courses work in various ways to lower blood sugar.

Sodium-glucose co-transporter 2 inhibitors

Jardiance is part of this class of medications. Examples of different medicine on this class embrace:

  • canagliflozin (Invokana)
  • dapagliflozin (Farxiga)
  • ertugliflozin (Steglatro)

Glucagon-like peptide-1 (GLP1) receptor agonists

Examples of medicine on this class embrace:

  • dulaglutide (Trulicity)
  • exenatide (Bydureon, Byetta)
  • liraglutide (Victoza)
  • lixisenatide (Adlyxin)
  • semaglutide (Ozempic)

Biguanide

  • metformin (Glucophage, Glumetza, Fortamet, Riomet)

Dipeptidyl peptidase-4 (DPP-Four) inhibitors

Examples of medicine in this class embrace:

  • alogliptin (Nesina)
  • sitagliptin (Januvia)
  • linagliptin (Tradjenta)
  • saxagliptin (Onglyza)

Thiazolidinediones

Examples of medicine in this class embrace:

  • pioglitazone (Actos)
  • rosiglitazone (Avandia)

Sulfonylureas

Examples of medicine on this class embrace:

  • chlorpropamide
  • glimepiride (Amaryl)
  • glipizide (Glucotrol)
  • glyburide (Diabeta, Glynase)

Options for preventing cardiovascular occasions in individuals with Sort 2 diabetes

Two medicine in addition to Jardiance have been FDA-approved to scale back sure cardiovascular risks in individuals with sort 2 diabetes and heart illness. These risks embrace demise from heart illness, which is what Jardiance is permitted to assist forestall.

These two medicine are:

  • liraglutide (Victoza), which is in a unique drug class than Jardiance (GLP-1 receptor agonist)
  • canagliflozin (Invokana), which is in the same drug class as Jardiance

Jardiance vs. different medicine

Chances are you’ll marvel how Jardiance compares to different drugs which might be prescribed to deal with Sort 2 diabetes. Under are comparisons between Jardiance and a number of other drugs.

Jardiance vs. Invokana

Jardiance accommodates the drug empagliflozin. Invokana accommodates the drug canagliflozin.

Jardiance and Invokana are each in the same class of medicines: sodium-glucose co-transporter (SGLT2) inhibitors. They work in the identical approach to deal with sort 2 diabetes.

Uses

Jardiance and Invokana are each FDA-approved to lower blood sugar ranges in adults with sort 2 diabetes. They’re authorised for use with food regimen and exercise.

Each medicine are additionally accredited to scale back certain risks in individuals with diabetes and heart disease:

  • Jardiance is accredited to scale back the danger of dying brought on by coronary heart disease.
  • Invokana is accepted to scale back the danger of great heart-related events, reminiscent of:
    • dying brought on by heart disease
    • nonfatal coronary heart assault
    • nonfatal stroke

Drug types and administration

Jardiance and Invokana each come as tablets which are taken by mouth as soon as day by day. Every ought to be taken in the morning.

Jardiance comes as 10-mg and 25-mg tablets. It may be taken with or with out meals.

Invokana comes as 100-mg and 300-mg tablets. It ought to be taken before the primary meal of the day.

Unwanted side effects and risks

Jardiance and Invokana include comparable medicine. Subsequently, both drugs may cause very comparable uncomfortable side effects. Under are examples of these unwanted side effects.

More widespread unwanted side effects

These lists include examples of extra widespread unwanted effects that can happen with Jardiance, with Invokana, or with both medicine (when taken individually).

  • Can happen with Jardiance:
    • few distinctive widespread unwanted side effects
  • Can happen with Invokana:
  • Can happen with both Jardiance and Invokana:

Critical unwanted side effects

These lists include examples of great uncomfortable side effects that may happen with Jardiance, with Invokana, or with each medicine (when taken individually).

  • Can occur with Jardiance:
    • few unique critical unwanted side effects
  • Can occur with Invokana:
    • bone fracture
    • decrease limb amputation
  • Can occur with both Jardiance and Invokana:
    • hypotension (low blood strain)
    • ketoacidosis
    • kidney damage
    • critical urinary tract infections
    • hypoglycemia (low blood sugar)
    • Fournier’s gangrene (severe infection near the genitals)
    • critical genital yeast infections
    • severe allergic reactions
    • increased ldl cholesterol

Effectiveness

In medical studies, Jardiance and Invokana have been both effective at treating sort 2 diabetes and decreasing sure heart-related risks. Nevertheless, these two medicine have not been in contrast immediately to each other in medical studies.

Prices

Jardiance and Invokana are each brand-name medicine. There are at present no generic types of either drug out there. Model-name drugs often value greater than generics.

In accordance with estimates from GoodRx.com, Jardiance and Invokana usually value about the identical. The actual worth you’d pay for either drug would depend in your dose, insurance coverage plan, your location, and the pharmacy you employ.

Jardiance vs. Farxiga

Jardiance accommodates the drug empagliflozin. Farxiga incorporates the drug dapagliflozin.

Jardiance and Farxiga are in the identical class of medications: sodium-glucose co-transporter 2 (SGLT2) inhibitors. They work in the identical approach to treat Sort 2 diabetes.

Makes use of

Jardiance and Farxiga are each FDA-approved to lower blood sugar levels in adults with sort 2 diabetes. They’re accepted for use in combination with weight-reduction plan and exercise.

Jardiance can also be permitted to scale back the danger of dying brought on by coronary heart illness in individuals with each Sort 2 diabetes and coronary heart disease.

Drug varieties and administration

Jardiance and Farxiga come as tablets which are taken by mouth once day by day. Both medicine ought to be taken in the morning. They are often taken with or without food.

Jardiance comes in 10-mg and 25-mg tablets. Farxiga is available in 5-mg and 10-mg tablets.

Uncomfortable side effects and risks

Jardiance and Farxiga include medicine from the same drug class. Subsequently, both drugs may cause very comparable uncomfortable side effects. Under are examples of these negative effects.

Extra widespread negative effects

These lists include examples of more widespread negative effects that can occur with Jardiance, with Farxiga, or with each medicine (when taken individually).

  • Can happen with Jardiance:
    • few unique widespread unwanted side effects
  • Can happen with Farxiga:
    • respiratory infections, such because the widespread cold
  • Can occur with both Jardiance and Farxiga:
    • urinary tract infections (UTI)
    • vaginal yeast infections

Critical unwanted effects

A lot of the critical unwanted side effects of Jardiance and Farxiga are comparable. This listing incorporates examples of great negative effects that may happen with each of these medicine.

  • Can occur with both Jardiance and Farxiga:
    • hypotension (low blood strain)
    • ketoacidosis
    • kidney damage
    • severe urinary tract infections (UTIs)
    • hypoglycemia (low blood sugar)
    • Fournier’s gangrene (severe an infection near the genitals)
    • severe genital yeast infections
    • elevated cholesterol
    • severe allergic reactions

Effectiveness

These medicine have not been immediately compared to each other in medical studies. Nevertheless, separate studies of Jardiance and Farxiga have found them each to be effective at decreasing blood sugar levels in individuals with sort 2 diabetes.

Prices

Jardiance and Farxiga are each brand-name medicine. There are at present no generic types of both drug out there. Brand-name drugs often value greater than generics.

In line with estimates from GoodRx.com, Jardiance and Farxiga usually value about the same. The precise worth you’d pay for either drug is dependent upon your insurance plan, your location, and the pharmacy you employ.

How Jardiance works

Jardiance helps decrease blood sugar levels in individuals with Sort 2 diabetes.

How insulin impacts blood sugar

Normally, the physique releases a hormone referred to as insulin once you eat food. Insulin helps move sugar (glucose) from the bloodstream into your body’s cells. Your cells flip the sugar into power.

People who have sort 2 diabetes are often immune to insulin. Which means their body doesn’t reply to insulin the best way it ought to. Over time, individuals with sort 2 diabetes may stop making insulin.

Without the assistance of insulin, your physique’s cells can’t take up glucose. This could have an effect on how nicely the cells work in your body. Your blood ranges of glucose can even develop into too excessive. Excessive blood glucose levels are referred to as hyperglycemia.

Excessive blood glucose ranges may cause many well being issues. Areas of the physique that can be affected embrace:

  • eyes
  • coronary heart
  • kidneys
  • nerves

What Jardiance does

Jardiance belongs to a drug class referred to as sodium-glucose co-transporter 2 (SGLT2) inhibitors. A drug class is a gaggle of medicines that work in very comparable methods inside the physique. Drugs in the same class or group are often used to treat the identical or comparable circumstances.

Jardiance lowers blood sugar ranges by causing the kidneys to eliminate extra sugar within the blood. The kidneys launch the additional glucose out of the physique by means of the urine.

Jardiance also reduces the danger of dying brought on by critical heart-related events. It does this by decreasing the physique’s blood strain. Jardiance increases urination, which reduces the quantity of fluid within the body. Having less fluid in the physique reduces blood strain. This puts less pressure on the guts and blood vessels.

How lengthy does it take to work?

Jardiance begins working within 30 to 60 minutes after you’re taking it. It might take several days to every week earlier than Jardiance has its full effect on decreasing your blood sugar ranges. If your doctor increases your dose, it might take longer to see the complete effects of the drug.

Find out how to take Jardiance

You need to take Jardiance in response to your doctor or healthcare provider’s directions.

When to take

Jardiance is taken by mouth as soon as every day. It must be taken in the morning.

Taking Jardiance with food

Jardiance could be taken with or with out meals.

Can Jardiance be crushed?

Jardiance tablets shouldn’t be crushed. If in case you have hassle swallowing Jardiance tablets, speak together with your doctor about different drugs that may be simpler so that you can take.

Jardiance value

As with all drugs, the cost of Jardiance can range. To seek out current prices for Jardiance in your space, take a look at GoodRx.com: